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We are going with Lanus because their substitute team has already shown that it adapts well in first-class and even has good results.
They already beat Aldosivi in Mar del Plata, they tied with Defense and Justice and they come from drawing with Patronato in Parana where they almost won it.
Central arrives with a hundred casualties, where its scorers are already out among several more starters. The speech of Vecchio and Marinelli: 

https://www.ellitoral.com/index.php/id_um/276651-rosario-central-visita-con-varias-bajas-a-los-suplentes-de-lanus-para-ser-primero-este-domingo- by-the-5-date-sports-copa-maradona.html? utm_source = dlvr.it & utm_medium = twitter

https://www.rosario3.com/deportes/Dos-nuevas-bajas-en-Central-por-posible-covid-y-el-Kily-pediria-la-postergacion-del-partido-con-Lanus-20210108- 0034.html? Utm_source = dlvr.it & utm_medium = twitter

Also remember that Central, even losing, already secures its first place. Union should win by 5 goals to get first place
La Cantera de Lanus is a reality, not for nothing does the first team of Lanus have many lower-level players, for that reason, I bet on locals handicap.